講者：wlchen
日期：2021-05-18
觀看: 599
  • 00:00 1.
    Slide 0
  • 00:06 2.
    HIV-1&-2 (RNA virus)
  • 01:56 3.
    病毒的蛋白gp41與gp120。gp41是跨膜蛋白，gp120位於表面；gp41和gp120會結合，就長得像棒棒糖一樣。
  • 08:27 4.
    Antiretroviral agents
  • 11:57 5.
    Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
  • 14:13 6.
    Nucleoside reverse transcriptase inhibitors (NRTI)
  • 15:39 7.
    Mechanism of action of NRTIs
  • 17:29 8.
    核苷反轉錄酶抑制劑
  • 18:48 9.
    Mechanism of action of NRTIs
  • 20:42 10.
    Abacavir
  • 23:33 11.
    藥物基因體學(Pharmacogenomics):基因和藥物反應的關係。
  • 25:11 12.
    Mechanism of action of NRTIs
  • 26:28 13.
    Mechanism of action of NRTIs
  • 27:27 14.
    Mechanism of action of NRTIs
  • 28:45 15.
    Mechanism of action of NRTIs
  • 30:00 16.
    Mechanism of action of NRTIs
  • 31:17 17.
    Nucleotide reversetranscriptase inhibitors (NtRTI)
  • 31:21 18.
    Nucleotide reversetranscriptase inhibitors (NtRTI)
  • 32:10 19.
    Tenofovir disoproxil fumarate
  • 33:31 20.
    核苷與核苷酸反轉錄酶抑制劑
  • 35:14 21.
    Non-nucleoside reversetranscriptase inhibitors(NNRTI)
  • 37:08 22.
    Slide 48
  • 37:41 23.
    NNRTIs
  • 39:31 24.
    可直接與反轉錄酶結合，藉由破壞酵素作用部位，阻斷具RNA 依賴性和DNA 依賴性的DNA 聚合酶活性，從而抑制病毒的繁殖。作用機制:inactive反轉錄酶。(抑制Reverse transcriptase) 結合在反轉錄酶活性區附近的疏水區(target at an allosteric “pocket”)，引起其催化部位構型上的變化，直接使反轉錄酶被抑制(direct inactivate the enzyme)，屬於非競爭的抑制作用。 NNRTIs (非核苷反轉錄酶抑制劑)與 NRTIs 不同之處在
  • 42:21 25.
    NNRTI
  • 44:03 26.
    NNRTI
  • 45:34 27.
    All of them are macromolecules PI competitively binds to the active site HIV protease and prevents it from cleaving the pro-form of viral proteins into the working machinery of the virus. If the HIV protease enzyme does not work, the virus is not infectio
  • 50:49 28.
    蛋白酶抑制劑 ( Protease inhibitors, PIs)
  • 53:18 29.
    Slide 55
  • 53:36 30.
    Darunavir
  • 54:24 31.
    蛋白酶抑制劑 ( Protease inhibitors)
  • 55:05 32.
    Protease inhibitors
  • 57:40 33.
    脂肪營養不良
  • 58:53 34.
    Protease inhibitors
  • 58:55 35.
    蛋白酶抑制劑 ( Protease inhibitors)
  • 58:56 36.
    Protease inhibitors
  • 58:56 37.
    脂肪營養不良
  • 1:00:28 38.
    Protease inhibitors
  • 1:00:45 39.
    脂肪營養不良
  • 1:00:46 40.
    IndinavirSide effect: Hyperbilirubinemia, nephrolithiasis (腎結石), nausea, diarrhea, headache, blurred vision, serum aminotransferase Metabolic alterations including hyperlipidemia (cholesterol or triglyceride  elevations) and hyperglycemiaLopinavirOnly
  • 1:02:55 41.
    Ritonavir: a potent inhibitor of CYP3A4 as a pharmacologic booster. It is often used to inhibit the enzyme that metabolizes other protease inhibitors. This inhibition leads to higher concentrations of these latter medication.Side effect: asthenia, GI dist
  • 1:06:36 42.
    Fusion inhibitor
  • 1:06:54 43.
    病毒的蛋白gp41與gp120。gp41是跨膜蛋白，gp120位於表面；gp41和gp120會結合，就長得像棒棒糖一樣。
  • 1:06:58 44.
    Fusion inhibitor
  • 1:07:00 45.
    病毒的蛋白gp41與gp120。gp41是跨膜蛋白，gp120位於表面；gp41和gp120會結合，就長得像棒棒糖一樣。
  • 1:07:25 46.
    Mechanism of action: binds to the gp41 subunit of the viral envelop glycoprotein, preventing the conformational changes required for the fusion of the viral and cellular membranes→ Enfuvirtide是一個HIV-1 gp41結構重組的抑制劑 (gp41是virus-cell fusion所必須)。 藥物阻斷融合蛋白(fus
  • 1:08:38 47.
    Viral entry inhibitor
  • 1:10:36 48.
    Viral entry inhibitor-1
  • 1:12:49 49.
    Integrase strand transfer inhibitor (INSTIs)
  • 1:15:55 50.
    雞尾酒療法HAART
  • 1:18:21 51.
    雞尾酒療法HAART
  • 1:20:18 52.
    Slide 70
  • 索引
  • 筆記
  • 討論
  • 全螢幕
chapter 49(學生)
長度: 1:21:28, 瀏覽: 599, 最近修訂: 2021-06-04
    上一篇
    • 00:00 1.
      Slide 0
    • 00:06 2.
      HIV-1&-2 (RNA virus)
    • 01:56 3.
      病毒的蛋白gp41與gp120。gp41是跨膜蛋白，gp120位於表面；gp41和gp120會結合，就長得像棒棒糖一樣。
    • 08:27 4.
      Antiretroviral agents
    • 11:57 5.
      Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
    • 14:13 6.
      Nucleoside reverse transcriptase inhibitors (NRTI)
    • 15:39 7.
      Mechanism of action of NRTIs
    • 17:29 8.
      核苷反轉錄酶抑制劑
    • 18:48 9.
      Mechanism of action of NRTIs
    • 20:42 10.
      Abacavir
    • 23:33 11.
      藥物基因體學(Pharmacogenomics):基因和藥物反應的關係。
    • 25:11 12.
      Mechanism of action of NRTIs
    • 26:28 13.
      Mechanism of action of NRTIs
    • 27:27 14.
      Mechanism of action of NRTIs
    • 28:45 15.
      Mechanism of action of NRTIs
    • 30:00 16.
      Mechanism of action of NRTIs
    • 31:17 17.
      Nucleotide reversetranscriptase inhibitors (NtRTI)
    • 31:21 18.
      Nucleotide reversetranscriptase inhibitors (NtRTI)
    • 32:10 19.
      Tenofovir disoproxil fumarate
    • 33:31 20.
      核苷與核苷酸反轉錄酶抑制劑
    • 35:14 21.
      Non-nucleoside reversetranscriptase inhibitors(NNRTI)
    • 37:08 22.
      Slide 48
    • 37:41 23.
      NNRTIs
    • 39:31 24.
      可直接與反轉錄酶結合，藉由破壞酵素作用部位，阻斷具RNA 依賴性和DNA 依賴性的DNA 聚合酶活性，從而抑制病毒的繁殖。作用機制:inactive反轉錄酶。(抑制Reverse transcriptase) 結合在反轉錄酶活性區附近的疏水區(target at an allosteric “pocket”)，引起其催化部位構型上的變化，直接使反轉錄酶被抑制(direct inactivate the enzyme)，屬於非競爭的抑制作用。 NNRTIs (非核苷反轉錄酶抑制劑)與 NRTIs 不同之處在
    • 42:21 25.
      NNRTI
    • 44:03 26.
      NNRTI
    • 45:34 27.
      All of them are macromolecules PI competitively binds to the active site HIV protease and prevents it from cleaving the pro-form of viral proteins into the working machinery of the virus. If the HIV protease enzyme does not work, the virus is not infectio
    • 50:49 28.
      蛋白酶抑制劑 ( Protease inhibitors, PIs)
    • 53:18 29.
      Slide 55
    • 53:36 30.
      Darunavir
    • 54:24 31.
      蛋白酶抑制劑 ( Protease inhibitors)
    • 55:05 32.
      Protease inhibitors
    • 57:40 33.
      脂肪營養不良
    • 58:53 34.
      Protease inhibitors
    • 58:55 35.
      蛋白酶抑制劑 ( Protease inhibitors)
    • 58:56 36.
      Protease inhibitors
    • 58:56 37.
      脂肪營養不良
    • 1:00:28 38.
      Protease inhibitors
    • 1:00:45 39.
      脂肪營養不良
    • 1:00:46 40.
      IndinavirSide effect: Hyperbilirubinemia, nephrolithiasis (腎結石), nausea, diarrhea, headache, blurred vision, serum aminotransferase Metabolic alterations including hyperlipidemia (cholesterol or triglyceride  elevations) and hyperglycemiaLopinavirOnly
    • 1:02:55 41.
      Ritonavir: a potent inhibitor of CYP3A4 as a pharmacologic booster. It is often used to inhibit the enzyme that metabolizes other protease inhibitors. This inhibition leads to higher concentrations of these latter medication.Side effect: asthenia, GI dist
    • 1:06:36 42.
      Fusion inhibitor
    • 1:06:54 43.
      病毒的蛋白gp41與gp120。gp41是跨膜蛋白，gp120位於表面；gp41和gp120會結合，就長得像棒棒糖一樣。
    • 1:06:58 44.
      Fusion inhibitor
    • 1:07:00 45.
      病毒的蛋白gp41與gp120。gp41是跨膜蛋白，gp120位於表面；gp41和gp120會結合，就長得像棒棒糖一樣。
    • 1:07:25 46.
      Mechanism of action: binds to the gp41 subunit of the viral envelop glycoprotein, preventing the conformational changes required for the fusion of the viral and cellular membranes→ Enfuvirtide是一個HIV-1 gp41結構重組的抑制劑 (gp41是virus-cell fusion所必須)。 藥物阻斷融合蛋白(fus
    • 1:08:38 47.
      Viral entry inhibitor
    • 1:10:36 48.
      Viral entry inhibitor-1
    • 1:12:49 49.
      Integrase strand transfer inhibitor (INSTIs)
    • 1:15:55 50.
      雞尾酒療法HAART
    • 1:18:21 51.
      雞尾酒療法HAART
    • 1:20:18 52.
      Slide 70
    位置
    1. 知識庫
    2. ...
    3. 109-2學期
    資料夾名稱
    109-2學期
    發表人
    劉淑芬
    單位
    藥學系
    建立
    2021-05-18 10:07:52
    最近修訂
    2021-06-04 07:26:58
    瀏覽
    599
    長度
    1:21:28
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